Mangosteen Fruit Information

Mangosteen Research

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Here are some of the research articles for the mangosteen fruit. For more, please visit www.pubmed.com.

Antiproliferative activity of Thai medicinal plant extracts on human breast adenocarcinoma cell line.

Moongkarndi P, Kosem N, Luanratana O, Jongsomboonkusol S, Pongpan N.

Department of Microbiology, Faculty of Pharmacy, Mahidol University, Rajdhevee, Sri Ayudthaya Rd, Bangkok 10400, Thailand. pypmk@mahidol.ac.th

Ethanolic extracts of selected nine Thai medicinal plants were tested for antiproliferative activity against SKBR3 human breast adenocarcinoma cell line using MTT assay. Garcinia mangostana showed the most potent activity. However, all plant extracts showed activity in potential range for further investigation on cancer cells. Copyright 2004 Elsevier B.V.

PMID: 15158999 [PubMed - indexed for MEDLINE]

Xanthones and benzophenones from Garcinia griffithii and Garcinia mangostana.

Nguyen LH, Venkatraman G, Sim KY, Harrison LJ.

Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Republic of Singapore.

A new polyisoprenylated benzophenone, guttiferone I, together with the known compounds cambogin, 1,7-dihydroxyxanthone, 1,3,6,7-tetrahydroxyxanthone and 1,3,5,6-tetrahydroxyxanthone were isolated from the stem bark of Garcinia griffithii. The acetone extract of the heartwood of Garcinia mangostana contained one new diprenylated xanthone (mangoxanthone) and a new benzophenone (3',6-dihydroxy-2,4,4'-trimethoxybenzophenone) as well as the known xanthones dulxanthone D, 1,3,7-trihydroxy-2-methoxyxanthone, 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran[7,6-b]xanthen-9-one. Their structures were established on the basis of spectroscopic studies and chemical correlation.

PMID: 16173114 [PubMed - indexed for MEDLINE]

Activity of medicinal plant extracts against hospital isolates of methicillin-resistant Staphylococcus aureus.

Voravuthikunchai SP, Kitpipit L.

Department of Microbiology, Faculty of Science, Prince of Songkla University, Hatyai, Songkla, Thailand. supayang.v@psu.ac.th

Aqueous and ethanolic extracts of ten traditional Thai medicinal plants were investigated for their ability to inhibit 35 hospital isolates of methicillin-resistant Staphylococcus aureus (MRSA). Nine medicinal plants displayed activity against all isolates tested. Ethanolic extracts of Garcinia mangostana, Punica granatum and Quercus infectoria were most effective, with MICs for MRSA isolates of 0.05-0.4, 0.2-0.4 and 0.2-0.4 mg/mL, respectively, and for S. aureus ATCC 25923 of 0.1, 0.2 and 0.1 mg/mL, respectively. MBCs for MRSA isolates were 0.1-0.4, 1.6-3.2 and 0.4-1.6 mg/mL, and for S. aureus ATCC 25923 were 0.4, 3.2 and 1.6 mg/mL, respectively.

PMID: 15882206 [PubMed - indexed for MEDLINE]

Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells.

Matsumoto K, Akao Y, Yi H, Ohguchi K, Ito T, Tanaka T, Kobayashi E, Iinuma M, Nozawa Y.

Gifu International Institute of Biotechnology, 1-1 Naka-Fudogaoka, Kakamigahara, Gifu 504-0838, Japan. kmatsumo@giib.or.jp

Our previous study has shown that alpha-mangostin, a xanthone from the pericarps of mangosteen, induces caspase-3-dependent apoptosis in HL60 cells. In the current study, we investigated the mechanism of apoptosis induced by alpha-mangostin in HL60 cells. Alpha-mangostin-treated HL60 cells demonstrated caspase-9 and -3 activation but not -8, which leads us to assume that alpha-mangostin may mediate the mitochondrial pathway in the apoptosis. Parameters of mitochondrial dysfunction including swelling, loss of membrane potential (deltapsim), decrease in intracellular ATP, ROS accumulation, and cytochrome c/AIF release, were observed within 1 or 2 h after the treatment. On the other hand, alpha-mangostin-treatment did not affect expression of bcl-2 family proteins and activation of MAP kinases. These findings indicate that alpha-mangostin preferentially targets mitochondria in the early phase, resulting in indication of apoptosis in HL60 cells. Furthermore, we examined the structure-activity relationship between xanthone derivatives including alpha-mangostin and the potency of deltapsim-loss in HL60 cells. Interestingly, replacement of hydroxyl group by methoxy group remarkably decreased its potency. It was also shown that the cytotoxicity substantially correlated with deltapsim decrease. These results indicate that alpha-mangostin and its analogs would be candidates for preventive and therapeutic application for cancer treatment.

PMID: 15498656 [PubMed - indexed for MEDLINE]

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10/15/2008
New Insight Into Bloom's Syndrome
Two independent papers in the October 15th issue of G&D detail the discovery of a previously unidentified fourth component of the Bloom's syndrome complex. Bloom's syndrome is an inherited cancer predisposition disease, resulting from mutations in a gene on the long arm of chromosome number 15. The BLM gene encodes for one part of a multi-enzyme Bloom's syndrome complex (called BTB) that facilitates DNA repair, and helps ensure the integrity of the genome.
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10/15/2008
Consensus Statement On Hepatitis B To Be Released By NIH Oct. 22
Hepatitis B is a major cause of liver disease worldwide, ranking as a substantial cause of cirrhosis and liver cancer. Approximately 1.25 million people are chronically infected with the virus in the United States, resulting in 3,000 to 5,000 deaths each year. The incomplete understanding of the natural history of the disease, coupled with multiple conflicting guidelines, make the management of this complex disease challenging.
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10/15/2008
116 Investigators At 75 Institutions Nationwide Receive Research Grants From The American Cancer Society
The American Cancer Society, the largest non-government, not-for-profit funding source of cancer research in the United States, has awarded 116 national research and training grants totaling more than $54 million in the first of two grant cycles for 2009. The grants are the first under a new realignment that created six major program areas in research and training. All of the grants go into effect January 1, 2009.
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10/15/2008
One In Eight Advanced Cancer Patients Delays, Avoids Needed Treatment Because Of Cost Concerns, Analysis Finds
One in eight advanced cancer patients delayed or avoided recommended treatment because of cost concerns, according to an analysis recently conducted by Thomson Reuters, USA Today reports. The unscientific analysis involved 1,767 patients who responded to an online questionnaire.
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10/15/2008
ICAD Introduces MRI Products To Help Improve Detection And Diagnosis Of Breast Cancer
iCAD, Inc.
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