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Aloe Vera Research
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Aloe Vera Research
Aloe Vera has been
studied extensively for it's amazing healing properties for intestinal help,
skin remedies and it's anti-inflammitory effects. Here are just a few
recent studies for aloe vera. For more research information visit pubmed.com
.
Anti-inflammatory effects of Aloe vera on
leukocyte-endothelium interaction in the gastric microcirculation of
Helicobacter pylori-infected rats.
Department of Physiology, Faculty of Medicine,
Chulalongkorn University, Bangkok 10330, Thailand.
This research was aimed to investigate anti-inflammatory
effects of Aloe vera on leukocyte-endothelium in the gastric
microcirculation of Helicobacter pylori (H. pylori)-infected rats.
Thirty-six male Sprague-Dawley rats were divided into 3 groups: control,
H. pylori-infected, and A. vera-treated group (200 mg/kg b.w., twice
daily). H. pylori-inoculation was induced in the rats by the
administration of H. pylori solution. Intravital fluorescence
videomicroscopy was used to examine leukocyte adhesion in postcapillary
venules on the posterior surface of stomach area on different periods
after administration of A. vera. Serum tumor necrosis factor-alpha
(TNF-alpha) level was measured in blood collected at the end of experiment
by using ELISA technique. The results showed that in H. pylori-infected
group on day 8, the leukocyte adhesion was 13.40+/-1.00 cells/100 microm
vessel length and the TNF-alpha was 76.76+/-23.18 pg/ml, which increased
significantly (p < 0.05), compared with the control group (leukocyte
adhesion(control) = 2.54+/-0.6 cells/100 microm vessel length and
TNF-alpha(control) = 9.92+/-2.62 pg/ml). Treatment with A. vera reduced
the leukocyte adhesion (5.5+/-0.5 cells/100 microm vessel length), and
TNF-alpha (26.31+/-6.38 pg/ml) significantly (p < 0.05). In conclusion,
H. pylori enhanced leukocyte-endothelium interaction in the posterior
stomach area markedly. This enhancement in leukocyte-endothelium
interaction could be improved by the treatment of A. vera, associated with
reduction in TNF-alpha level.
PMID: 16899957 [PubMed - indexed for MEDLINE]
The effect of Aloe vera A. Berger (Liliaceae) on gastric
acid secretion and acute gastric mucosal injury in rats.
Department of Human Physiology, Ahmadu Bello
University, Zaria, Nigeria. sadiqyusuf@yahoo.com
The effect of varying doses of ethanol extract of Aloe
vera (Liliaceae) on acute gastric mucosal lesions induced by 0.6 M HCl and
acid output was studied in the pylorus ligated and lumen perfuse rats,
respectively. Acid secretion was determined by titration of the collected
gastric juice to pH 7.0. Intraperitoneal injection of Aloe vera, dose
dependently inhibited gastric acid secretion. The plant was more active as
a gastroprotective agent at lower concentration against mucosal injury
induced by 0.6 M HCl. In conclusion, Aloe vera is endowed with gastric
acid anti-secretory activity and could protect the gastric mucosa at low
concentrations against injurious agents.
PMID: 15182901 [PubMed - indexed for MEDLINE]
Antidiabetic effects of dietary administration of Aloe
arborescens Miller components on multiple low-dose streptozotocin-induced
diabetes in mice: investigation on hypoglycemic action and systemic
absorption dynamics of aloe components.
Fujita Memorial Nanakuri Institute, Fujita Health
University, 1865 Isshiki-cho, Hisai, Mie 514-1296, Japan.
hbeppu@fujita-hu.ac.jp
We carried out three experimental trials to determine
antidiabetic effects of Aloe arborescens Miller components. Firstly, ICR
mice which received frequent injections of streptozotocin (Sz) in small
doses (low-dose Sz-induced diabetes mice) were fed ad libitum with basal
diets supplemented with components of Aloe arborescens Miller var.
natalensis Berger (Kidachi aloe) and Aloe vera Linne from 31 days before
to 73 days after the Sz injections. Variation in blood glucose levels,
incidence rates of insulitis and blood insulin levels were examined during
the trial. As a result, groups receiving diets supplemented at the rate of
2% with whole leaf of Kidachi aloe and 10 KDa fraction powder (a fraction
with less than 10 KDa molecular weight derived from Kidachi aloe leaf skin
juice by ultra filtration) significantly suppressed the elevation of blood
sugar as compared to a control group receiving basal diet. In contrast,
there was no significant effect with Aloe vera leaf pulp powder. Insulitis
emerged at the rate of 87% in the basal diet group. On the contrary, the
whole aloe leaf and 10 KDa fraction groups significantly decreased the
incidence of insulitis and incidence rates of whole aloe leaf and 10 KDa
fraction powder were 51 and 38%, respectively. While insulin levels in the
basal diet group averaged at 0.05 ng, more than four times the insulin
level was observed in the 10 KDa group relative to the basal diet group.
Secondary, the inhibitory effects of test materials on intestinal glucose
absorption were observed using the jejunum of rats. A strong inhibitory
action on intestinal glucose absorption was observed in the 10 KDa
fraction powder group. Thirdly, phenol compounds derived from aloe in the
blood serum and organs were quantitatively measured by a HPLC following
forced administration of aloe components to rats to determine absorption
kinetics of aloe components inside the body. The primary component of aloe
phenol compounds is the same component of the 10 KDa fraction powder and
it was found in the pancreas and liver in addition to in the blood serum.
The above results indicate that fore and aft when Sz injections could
cause selective toxicity to B cells of islets, the dietary administration
of 10 KDa fraction powder to mice would lead to the persistence of aloe
phenol compound having an antioxidant activity in the pancreas and blood,
which could protect islets of Langerhans from the destruction caused by
methyl radical derived from Sz. The results also suggested the possibility
of the 10 KDa fraction powder to alleviate the burden of insulin secretion
as it has an inhibitory action on glucose absorption in the jejunum of
rats.
PMID: 16406411 [PubMed - in process]
All natural fruit, herbs and remedies will affect people
differently because our body chemistry's are different. So, start slow
and be patient. If you aren't having an adverse reaction to any particular remedy,
make sure you try it for 60-90 days to give it a fair trial. Frequently
some results can be noticed within weeks, but many take a little longer.
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